diff --git a/src/drawer.js b/src/drawer.js
index fca4b956..30d7fcf2 100644
--- a/src/drawer.js
+++ b/src/drawer.js
@@ -344,15 +344,18 @@ $.Drawer.prototype = {
      * where <code>rendered</code> is the context with the pre-drawn image.
      * @param {Float} [scale=1] - Apply a scale to tile position and size. Defaults to 1.
      * @param {OpenSeadragon.Point} [translate] A translation vector to offset tile position
+     * @param {Boolean} [shouldRoundPositionAndSize] - Tells whether to round
+     * position and size of tiles supporting alpha channel in non-transparency
+     * context.
      */
-    drawTile: function(tile, drawingHandler, useSketch, scale, translate) {
+    drawTile: function(tile, drawingHandler, useSketch, scale, translate, shouldRoundPositionAndSize) {
         $.console.assert(tile, '[Drawer.drawTile] tile is required');
         $.console.assert(drawingHandler, '[Drawer.drawTile] drawingHandler is required');
 
         if (this.useCanvas) {
             var context = this._getContext(useSketch);
             scale = scale || 1;
-            tile.drawCanvas(context, drawingHandler, scale, translate);
+            tile.drawCanvas(context, drawingHandler, scale, translate, shouldRoundPositionAndSize);
         } else {
             tile.drawHTML( this.canvas );
         }
diff --git a/src/openseadragon.js b/src/openseadragon.js
index f84ebfb1..4f982eba 100644
--- a/src/openseadragon.js
+++ b/src/openseadragon.js
@@ -209,6 +209,17 @@
   *     You can pass a CSS color value like "#FF8800".
   *     When passing a function the tiledImage and canvas context are available as argument which is useful when you draw a gradient or pattern.
   *
+  * @property {Object} [subPixelRoundingForTransparency=null]
+  *     Determines when subpixel rounding should be applied for tiles when rendering images that support transparency.
+  *     This property is a subpixel rounding enum values dictionary [{@link BROWSERS}] --> {@link SUBPIXEL_ROUNDING_OCCURRENCES}.
+  *     The key is a {@link BROWSERS} value, and the value is one of {@link SUBPIXEL_ROUNDING_OCCURRENCES},
+  *     indicating, for a given browser, when to apply subpixel rounding.
+  *     Key '*' is the fallback value for any browser not specified in the dictionary.
+  *     This property has a simple mode, and one can set it directly to
+  *     {@link SUBPIXEL_ROUNDING_OCCURRENCES.NEVER}, {@link SUBPIXEL_ROUNDING_OCCURRENCES.ONLY_AT_REST} or {@link SUBPIXEL_ROUNDING_OCCURRENCES.ALWAYS}
+  *     in order to apply this rule for all browser. The values {@link SUBPIXEL_ROUNDING_OCCURRENCES.ALWAYS} would be equivalent to { '*', SUBPIXEL_ROUNDING_OCCURRENCES.ALWAYS }.
+  *     The default is {@link SUBPIXEL_ROUNDING_OCCURRENCES.NEVER} for all browsers, for backward compatibility reason.
+  *
   * @property {Number} [degrees=0]
   *     Initial rotation.
   *
@@ -1258,11 +1269,12 @@ function OpenSeadragon( options ){
             flipped:                    false,
 
             // APPEARANCE
-            opacity:                    1,
-            preload:                    false,
-            compositeOperation:         null,
-            imageSmoothingEnabled:      true,
-            placeholderFillStyle:       null,
+            opacity:                           1,
+            preload:                           false,
+            compositeOperation:                null,
+            imageSmoothingEnabled:             true,
+            placeholderFillStyle:              null,
+            subPixelRoundingForTransparency:   null,
 
             //REFERENCE STRIP SETTINGS
             showReferenceStrip:          false,
@@ -1403,6 +1415,20 @@ function OpenSeadragon( options ){
             CHROMEEDGE: 7
         },
 
+        /**
+         * An enumeration of when subpixel rounding should occur.
+         * @static
+         * @type {Object}
+         * @property {Number} NEVER Never apply subpixel rounding for transparency.
+         * @property {Number} ONLY_AT_REST Do not apply subpixel rounding for transparency during animation (panning, zoom, rotation) and apply it once animation is over.
+         * @property {Number} ALWAYS Apply subpixel rounding for transparency during animation and when animation is over.
+         */
+        SUBPIXEL_ROUNDING_OCCURRENCES: {
+            NEVER:        0,
+            ONLY_AT_REST: 1,
+            ALWAYS:       2
+        },
+
         /**
          * Keep track of which {@link Viewer}s have been created.
          * - Key: {@link Element} to which a Viewer is attached.
diff --git a/src/tile.js b/src/tile.js
index 701db750..f003c157 100644
--- a/src/tile.js
+++ b/src/tile.js
@@ -318,8 +318,11 @@ $.Tile.prototype = {
      * where <code>rendered</code> is the context with the pre-drawn image.
      * @param {Number} [scale=1] - Apply a scale to position and size
      * @param {OpenSeadragon.Point} [translate] - A translation vector
+     * @param {Boolean} [shouldRoundPositionAndSize] - Tells whether to round
+     * position and size of tiles supporting alpha channel in non-transparency
+     * context.
      */
-    drawCanvas: function( context, drawingHandler, scale, translate ) {
+    drawCanvas: function( context, drawingHandler, scale, translate, shouldRoundPositionAndSize ) {
 
         var position = this.position.times($.pixelDensityRatio),
             size     = this.size.times($.pixelDensityRatio),
@@ -363,6 +366,14 @@ $.Tile.prototype = {
         //an image with an alpha channel, then the only way
         //to avoid seeing the tile underneath is to clear the rectangle
         if (context.globalAlpha === 1 && this._hasTransparencyChannel()) {
+            if (shouldRoundPositionAndSize) {
+                // Round to the nearest whole pixel so we don't get seams from overlap.
+                position.x = Math.round(position.x);
+                position.y = Math.round(position.y);
+                size.x = Math.round(size.x);
+                size.y = Math.round(size.y);
+            }
+
             //clearing only the inside of the rectangle occupied
             //by the png prevents edge flikering
             context.clearRect(
diff --git a/src/tiledimage.js b/src/tiledimage.js
index 1942c75c..2817710f 100644
--- a/src/tiledimage.js
+++ b/src/tiledimage.js
@@ -160,24 +160,25 @@ $.TiledImage = function( options ) {
         _hasOpaqueTile: false,  // Do we have even one fully opaque tile?
         _tilesLoading:  0,     // The number of pending tile requests.
         //configurable settings
-        springStiffness:        $.DEFAULT_SETTINGS.springStiffness,
-        animationTime:          $.DEFAULT_SETTINGS.animationTime,
-        minZoomImageRatio:      $.DEFAULT_SETTINGS.minZoomImageRatio,
-        wrapHorizontal:         $.DEFAULT_SETTINGS.wrapHorizontal,
-        wrapVertical:           $.DEFAULT_SETTINGS.wrapVertical,
-        immediateRender:        $.DEFAULT_SETTINGS.immediateRender,
-        blendTime:              $.DEFAULT_SETTINGS.blendTime,
-        alwaysBlend:            $.DEFAULT_SETTINGS.alwaysBlend,
-        minPixelRatio:          $.DEFAULT_SETTINGS.minPixelRatio,
-        smoothTileEdgesMinZoom: $.DEFAULT_SETTINGS.smoothTileEdgesMinZoom,
-        iOSDevice:              $.DEFAULT_SETTINGS.iOSDevice,
-        debugMode:              $.DEFAULT_SETTINGS.debugMode,
-        crossOriginPolicy:      $.DEFAULT_SETTINGS.crossOriginPolicy,
-        ajaxWithCredentials:    $.DEFAULT_SETTINGS.ajaxWithCredentials,
-        placeholderFillStyle:   $.DEFAULT_SETTINGS.placeholderFillStyle,
-        opacity:                $.DEFAULT_SETTINGS.opacity,
-        preload:                $.DEFAULT_SETTINGS.preload,
-        compositeOperation:     $.DEFAULT_SETTINGS.compositeOperation
+        springStiffness:                   $.DEFAULT_SETTINGS.springStiffness,
+        animationTime:                     $.DEFAULT_SETTINGS.animationTime,
+        minZoomImageRatio:                 $.DEFAULT_SETTINGS.minZoomImageRatio,
+        wrapHorizontal:                    $.DEFAULT_SETTINGS.wrapHorizontal,
+        wrapVertical:                      $.DEFAULT_SETTINGS.wrapVertical,
+        immediateRender:                   $.DEFAULT_SETTINGS.immediateRender,
+        blendTime:                         $.DEFAULT_SETTINGS.blendTime,
+        alwaysBlend:                       $.DEFAULT_SETTINGS.alwaysBlend,
+        minPixelRatio:                     $.DEFAULT_SETTINGS.minPixelRatio,
+        smoothTileEdgesMinZoom:            $.DEFAULT_SETTINGS.smoothTileEdgesMinZoom,
+        iOSDevice:                         $.DEFAULT_SETTINGS.iOSDevice,
+        debugMode:                         $.DEFAULT_SETTINGS.debugMode,
+        crossOriginPolicy:                 $.DEFAULT_SETTINGS.crossOriginPolicy,
+        ajaxWithCredentials:               $.DEFAULT_SETTINGS.ajaxWithCredentials,
+        placeholderFillStyle:              $.DEFAULT_SETTINGS.placeholderFillStyle,
+        opacity:                           $.DEFAULT_SETTINGS.opacity,
+        preload:                           $.DEFAULT_SETTINGS.preload,
+        compositeOperation:                $.DEFAULT_SETTINGS.compositeOperation,
+        subPixelRoundingForTransparency:   $.DEFAULT_SETTINGS.subPixelRoundingForTransparency
     }, options );
 
     this._preload = this.preload;
@@ -1951,6 +1952,73 @@ function compareTiles( previousBest, tile ) {
     return previousBest;
 }
 
+/**
+ * @private
+ * @inner
+ * Defines the value for subpixel rounding to fallback to in case of missing or
+ * invalid value.
+ */
+var DEFAULT_SUBPIXEL_ROUNDING_RULE = $.SUBPIXEL_ROUNDING_OCCURRENCES.NEVER;
+
+/**
+ * @private
+ * @inner
+ * Checks whether the input value is an invalid subpixel rounding enum value.
+ *
+ * @param {SUBPIXEL_ROUNDING_OCCURRENCES} value - The subpixel rounding enum value to check.
+ * @returns {Boolean} Returns true if the input value is none of the expected
+ * {@link SUBPIXEL_ROUNDING_OCCURRENCES.ALWAYS}, {@link SUBPIXEL_ROUNDING_OCCURRENCES.ONLY_AT_REST} or {@link SUBPIXEL_ROUNDING_OCCURRENCES.NEVER} value.
+ */
+ function isSubPixelRoundingRuleUnknown(value) {
+    return value !== $.SUBPIXEL_ROUNDING_OCCURRENCES.ALWAYS &&
+        value !== $.SUBPIXEL_ROUNDING_OCCURRENCES.ONLY_AT_REST &&
+        value !== $.SUBPIXEL_ROUNDING_OCCURRENCES.NEVER;
+}
+
+/**
+ * @private
+ * @inner
+ * Ensures the returned value is always a valid subpixel rounding enum value,
+ * defaulting to {@link SUBPIXEL_ROUNDING_OCCURRENCES.NEVER} if input is missing or invalid.
+ *
+ * @param {SUBPIXEL_ROUNDING_OCCURRENCES} value - The subpixel rounding enum value to normalize.
+ * @returns {SUBPIXEL_ROUNDING_OCCURRENCES} Returns a valid subpixel rounding enum value.
+ */
+ function normalizeSubPixelRoundingRule(value) {
+    if (isSubPixelRoundingRuleUnknown(value)) {
+        return DEFAULT_SUBPIXEL_ROUNDING_RULE;
+    }
+    return value;
+}
+
+/**
+ * @private
+ * @inner
+ * Ensures the returned value is always a valid subpixel rounding enum value,
+ * defaulting to 'NEVER' if input is missing or invalid.
+ *
+ * @param {Object} subPixelRoundingRules - A subpixel rounding enum values dictionary [{@link BROWSERS}] --> {@link SUBPIXEL_ROUNDING_OCCURRENCES}.
+ * @returns {SUBPIXEL_ROUNDING_OCCURRENCES} Returns the determined subpixel rounding enum value for the
+ * current browser.
+ */
+function determineSubPixelRoundingRule(subPixelRoundingRules) {
+    if (typeof subPixelRoundingRules === 'number') {
+        return normalizeSubPixelRoundingRule(subPixelRoundingRules);
+    }
+
+    if (!subPixelRoundingRules || !$.Browser) {
+        return DEFAULT_SUBPIXEL_ROUNDING_RULE;
+    }
+
+    var subPixelRoundingRule = subPixelRoundingRules[$.Browser.vendor];
+
+    if (isSubPixelRoundingRuleUnknown(subPixelRoundingRule)) {
+        subPixelRoundingRule = subPixelRoundingRules['*'];
+    }
+
+    return normalizeSubPixelRoundingRule(subPixelRoundingRule);
+}
+
 /**
  * @private
  * @inner
@@ -2099,9 +2167,20 @@ function drawTiles( tiledImage, lastDrawn ) {
         tiledImage._drawer.drawRectangle(placeholderRect, fillStyle, useSketch);
     }
 
+    var subPixelRoundingRule = determineSubPixelRoundingRule(tiledImage.subPixelRoundingForTransparency);
+
+    var shouldRoundPositionAndSize = false;
+
+    if (subPixelRoundingRule === $.SUBPIXEL_ROUNDING_OCCURRENCES.ALWAYS) {
+        shouldRoundPositionAndSize = true;
+    } else if (subPixelRoundingRule === $.SUBPIXEL_ROUNDING_OCCURRENCES.ONLY_AT_REST) {
+        var isAnimating = tiledImage.viewer && tiledImage.viewer.isAnimating();
+        shouldRoundPositionAndSize = !isAnimating;
+    }
+
     for (var i = lastDrawn.length - 1; i >= 0; i--) {
         tile = lastDrawn[ i ];
-        tiledImage._drawer.drawTile( tile, tiledImage._drawingHandler, useSketch, sketchScale, sketchTranslate );
+        tiledImage._drawer.drawTile( tile, tiledImage._drawingHandler, useSketch, sketchScale, sketchTranslate, shouldRoundPositionAndSize );
         tile.beingDrawn = true;
 
         if( tiledImage.viewer ){
diff --git a/src/viewer.js b/src/viewer.js
index 9bc939aa..b1a60446 100644
--- a/src/viewer.js
+++ b/src/viewer.js
@@ -713,6 +713,7 @@ $.extend( $.Viewer.prototype, $.EventSource.prototype, $.ControlDock.prototype,
         }
 
         THIS[ this.hash ].animating = false;
+
         this.world.removeAll();
         this.imageLoader.clear();
 
@@ -1503,7 +1504,8 @@ $.extend( $.Viewer.prototype, $.EventSource.prototype, $.ControlDock.prototype,
                     ajaxWithCredentials: queueItem.options.ajaxWithCredentials,
                     loadTilesWithAjax: queueItem.options.loadTilesWithAjax,
                     ajaxHeaders: queueItem.options.ajaxHeaders,
-                    debugMode: _this.debugMode
+                    debugMode: _this.debugMode,
+                    subPixelRoundingForTransparency: _this.subPixelRoundingForTransparency
                 });
 
                 if (_this.collectionMode) {
@@ -2357,6 +2359,10 @@ $.extend( $.Viewer.prototype, $.EventSource.prototype, $.ControlDock.prototype,
         }
         this.goToPage( next );
     },
+
+    isAnimating: function () {
+        return THIS[ this.hash ].animating;
+    },
 });
 
 
@@ -3503,7 +3509,9 @@ function updateOnce( viewer ) {
         animated = viewer.referenceStrip.update( viewer.viewport ) || animated;
     }
 
-    if ( !THIS[ viewer.hash ].animating && animated ) {
+    var currentAnimating = THIS[ viewer.hash ].animating;
+
+    if ( !currentAnimating && animated ) {
         /**
          * Raised when any spring animation starts (zoom, pan, etc.).
          *
@@ -3517,7 +3525,13 @@ function updateOnce( viewer ) {
         abortControlsAutoHide( viewer );
     }
 
-    if ( animated || THIS[ viewer.hash ].forceRedraw || viewer.world.needsDraw() ) {
+    var isAnimationFinished = currentAnimating && !animated;
+
+    if ( isAnimationFinished ) {
+        THIS[ viewer.hash ].animating = false;
+    }
+
+    if ( animated || isAnimationFinished || THIS[ viewer.hash ].forceRedraw || viewer.world.needsDraw() ) {
         drawWorld( viewer );
         viewer._drawOverlays();
         if( viewer.navigator ){
@@ -3541,7 +3555,7 @@ function updateOnce( viewer ) {
         }
     }
 
-    if ( THIS[ viewer.hash ].animating && !animated ) {
+    if ( isAnimationFinished ) {
         /**
          * Raised when any spring animation ends (zoom, pan, etc.).
          *