Simplified imageSmoothingEnabled Option. The option can be set during viewer creation and also later with the function viewer.drawer.setImageSmoothingEnabled().

src/drawer.js

@@ -600,6 +600,28 @@ $.Drawer.prototype = {
         }
     },
 
+
+    /**
+     * Turns image smoothing on or off for this viewer. Note: Ignored in some (especially older) browsers that do not support this property.
+     *
+     * @function
+     * @param {Boolean} [imageSmoothingEnabled] - Whether or not the image is
+     * drawn smoothly on the canvas; see imageSmoothingEnabled in
+     * {@link OpenSeadragon.Options} for more explanation.
+     */
+    setImageSmoothingEnabled: function(imageSmoothingEnabled){
+        if ( this.useCanvas ) {
+            this.context.mozImageSmoothingEnabled = imageSmoothingEnabled;
+            this.context.webkitImageSmoothingEnabled = imageSmoothingEnabled;
+            this.context.msImageSmoothingEnabled = imageSmoothingEnabled;
+            this.context.imageSmoothingEnabled = imageSmoothingEnabled;
+
+            this.context.restore();
+
+            this.viewer.world.draw();
+        }
+    },
+
     /**
      * Get the canvas size
      * @param {Boolean} sketch If set to true return the size of the sketch canvas

src/openseadragon.js

@@ -198,6 +198,11 @@
   *     'destination-over', 'destination-atop', 'destination-in',
   *     'destination-out', 'lighter', 'copy' or 'xor'
   *
+  * @property {Boolean} [imageSmoothingEnabled=true]
+  *     Image smoothing for canvas rendering (only if canvas is used). Note: Ignored
+  *     by some (especially older) browsers which do not support this canvas property.
+  *     This property can be changed in {@link Viewer.Drawer.setImageSmoothingEnabled}.
+  *
   * @property {String|CanvasGradient|CanvasPattern|Function} [placeholderFillStyle=null]
   *     Draws a colored rectangle behind the tile if it is not loaded yet.
   *     You can pass a CSS color value like "#FF8800".
@@ -1178,6 +1183,7 @@ function OpenSeadragon( options ){
             opacity:                    1,
             preload:                    false,
             compositeOperation:         null,
+            imageSmoothingEnabled:      true,
             placeholderFillStyle:       null,
 
             //REFERENCE STRIP SETTINGS

src/viewer.js

@@ -466,6 +466,12 @@ $.Viewer = function( options ) {
     $.requestAnimationFrame( function(){
         beginControlsAutoHide( _this );
     } );
+
+    // Initial canvas options
+    if ( this.imageSmoothingEnabled !== undefined && !this.imageSmoothingEnabled){
+        this.drawer.setImageSmoothingEnabled(this.imageSmoothingEnabled);
+    }
+
 };
 
 $.extend( $.Viewer.prototype, $.EventSource.prototype, $.ControlDock.prototype, /** @lends OpenSeadragon.Viewer.prototype */{