diff --git a/src/net/dns/dns_reloader.cc b/src/net/dns/dns_reloader.cc
index 43cc164e20..f9db45b970 100644
--- a/src/net/dns/dns_reloader.cc
+++ b/src/net/dns/dns_reloader.cc
@@ -64,20 +64,32 @@ class DnsReloader : public NetworkChangeNotifier::DNSObserver {
     if (!reload_state) {
       auto new_reload_state = std::make_unique<ReloadState>();
       new_reload_state->resolver_generation = resolver_generation_;
+#ifdef __MUSL__
+      res_init();
+#else
       res_ninit(&_res);
+#endif
       tls_reload_state_.Set(std::move(new_reload_state));
     } else if (reload_state->resolver_generation != resolver_generation_) {
       reload_state->resolver_generation = resolver_generation_;
       // It is safe to call res_nclose here since we know res_ninit will have
       // been called above.
+#ifdef __MUSL__
+      res_init();
+#else
       res_nclose(&_res);
       res_ninit(&_res);
+#endif
     }
   }
 
  private:
   struct ReloadState {
-    ~ReloadState() { res_nclose(&_res); }
+    ~ReloadState() {
+#ifndef __MUSL__
+      res_nclose(&_res);
+#endif
+    }
 
     int resolver_generation;
   };
diff --git a/src/net/dns/public/scoped_res_state.cc b/src/net/dns/public/scoped_res_state.cc
index 9706d18b0f..0f619eedac 100644
--- a/src/net/dns/public/scoped_res_state.cc
+++ b/src/net/dns/public/scoped_res_state.cc
@@ -13,7 +13,7 @@
 namespace net {
 
 ScopedResState::ScopedResState() {
-#if BUILDFLAG(IS_OPENBSD) || BUILDFLAG(IS_FUCHSIA)
+#if BUILDFLAG(IS_OPENBSD) || BUILDFLAG(IS_FUCHSIA) || defined(__MUSL__)
   // Note: res_ninit in glibc always returns 0 and sets RES_INIT.
   // res_init behaves the same way.
   memset(&_res, 0, sizeof(_res));
@@ -25,7 +25,7 @@ ScopedResState::ScopedResState() {
 }
 
 ScopedResState::~ScopedResState() {
-#if !BUILDFLAG(IS_OPENBSD) && !BUILDFLAG(IS_FUCHSIA)
+#if !BUILDFLAG(IS_OPENBSD) && !BUILDFLAG(IS_FUCHSIA) && !defined(__MUSL__)
 
   // Prefer res_ndestroy where available.
 #if BUILDFLAG(IS_APPLE) || BUILDFLAG(IS_FREEBSD)
@@ -43,7 +43,7 @@ bool ScopedResState::IsValid() const {
 
 const struct __res_state& ScopedResState::state() const {
   DCHECK(IsValid());
-#if BUILDFLAG(IS_OPENBSD) || BUILDFLAG(IS_FUCHSIA)
+#if BUILDFLAG(IS_OPENBSD) || BUILDFLAG(IS_FUCHSIA) || defined(__MUSL__)
   return _res;
 #else
   return res_;