diff --git a/src/build/config/compiler/BUILD.gn b/src/build/config/compiler/BUILD.gn
index 5391a83edf..62e80c786b 100644
--- a/src/build/config/compiler/BUILD.gn
+++ b/src/build/config/compiler/BUILD.gn
@@ -143,6 +143,8 @@ declare_args() {
   # This allows to make behavior of uninitialized memory bugs consistent, easier to
   # recognize when debugging and often just to crash immediately.
   init_stack_vars = false
+
+  is_openwrt = false
 }
 
 declare_args() {
@@ -576,6 +578,11 @@ config("compiler") {
     ldflags += [ "-stdlib=libc++" ]
   }
 
+  if (is_openwrt && current_cpu == target_cpu) {
+    defines += [ "_LIBCPP_HAS_MUSL_LIBC", "__UCLIBC__" ]
+    libs = [ "atomic" ]
+  }
+
   # Add flags for link-time optimization. These flags enable
   # optimizations/transformations that require whole-program visibility at link
   # time, so they need to be applied to all translation units, and we may end up
@@ -779,6 +786,9 @@ config("compiler_cpu_abi") {
           if (is_android) {
             cflags += [ "--target=mipsel-linux-android" ]
             ldflags += [ "--target=mipsel-linux-android" ]
+          } else if (is_openwrt) {
+            cflags += [ "--target=mipsel-openwrt-linux-musl" ]
+            ldflags += [ "--target=mipsel-openwrt-linux-musl" ]
           } else {
             cflags += [ "--target=mipsel-linux-gnu" ]
             ldflags += [ "--target=mipsel-linux-gnu" ]
@@ -861,8 +871,13 @@ config("compiler_cpu_abi") {
       ldflags += [ "-Wl,--hash-style=sysv" ]
       if (custom_toolchain == "") {
         if (is_clang) {
-          cflags += [ "--target=mips-linux-gnu" ]
-          ldflags += [ "--target=mips-linux-gnu" ]
+          if (is_openwrt) {
+            cflags += [ "--target=mips-openwrt-linux-musl" ]
+            ldflags += [ "--target=mips-openwrt-linux-musl" ]
+          } else {
+            cflags += [ "--target=mips-linux-gnu" ]
+            ldflags += [ "--target=mips-linux-gnu" ]
+          }
         } else {
           cflags += [ "-EB" ]
           ldflags += [ "-EB" ]
@@ -910,6 +925,9 @@ config("compiler_cpu_abi") {
           if (is_android) {
             cflags += [ "--target=mips64el-linux-android" ]
             ldflags += [ "--target=mips64el-linux-android" ]
+          } else if (is_openwrt) {
+            cflags += [ "--target=mips64el-openwrt-linux-musl" ]
+            ldflags += [ "--target=mips64el-openwrt-linux-musl" ]
           } else {
             cflags += [ "--target=mips64el-linux-gnuabi64" ]
             ldflags += [ "--target=mips64el-linux-gnuabi64" ]
@@ -970,8 +988,13 @@ config("compiler_cpu_abi") {
       ldflags += [ "-Wl,--hash-style=sysv" ]
       if (custom_toolchain == "") {
         if (is_clang) {
-          cflags += [ "--target=mips64-linux-gnuabi64" ]
-          ldflags += [ "--target=mips64-linux-gnuabi64" ]
+          if (is_openwrt) {
+            cflags += [ "--target=mips64-openwrt-linux-musl" ]
+            ldflags += [ "--target=mips64-openwrt-linux-musl" ]
+          } else {
+            cflags += [ "--target=mips64-linux-gnuabi64" ]
+            ldflags += [ "--target=mips64-linux-gnuabi64" ]
+          }
         } else {
           cflags += [
             "-EB",
diff --git a/src/build/config/gcc/BUILD.gn b/src/build/config/gcc/BUILD.gn
index 747245f376..6c0a1a431c 100644
--- a/src/build/config/gcc/BUILD.gn
+++ b/src/build/config/gcc/BUILD.gn
@@ -108,6 +108,11 @@ config("executable_config") {
       "-Wl,--disable-new-dtags",
     ]
   }
+
+  # Needed for non-standard ldso on OpenWRT
+  if (ldso_path != "" && current_cpu == target_cpu) {
+    ldflags += [ "-Wl,--dynamic-linker=${ldso_path}" ]
+  }
 }
 
 # Settings for shared libraries.