diff --git a/select2.js b/select2.js
index f063563f..a0661148 100644
--- a/select2.js
+++ b/select2.js
@@ -1486,6 +1486,9 @@ the specific language governing permissions and limitations under the Apache Lic
 
             this.clearSearch();
             this.search.removeClass("select2-active");
+
+            // Remove the aria active descendant for highlighted element
+            this.search.removeAttr("aria-activedescendant");
             this.opts.element.trigger($.Event("select2-close"));
         },