Opening a new database connection in Doctrine is very easy. If you wish to use PDO (www.php.net/PDO) you can just initalize a new PDO object: \$dsn = 'mysql:dbname=testdb;host=127.0.0.1'; \$user = 'dbuser'; \$password = 'dbpass'; try { \$dbh = new PDO(\$dsn, \$user, \$password); } catch (PDOException \$e) { echo 'Connection failed: ' . \$e->getMessage(); } ?> If your database extension isn't supported by PDO you can use special Doctrine_Adapter class (if availible). The following example uses db2 adapter: \$dsn = 'db2:dbname=testdb;host=127.0.0.1'; \$user = 'dbuser'; \$password = 'dbpass'; try { \$dbh = Doctrine_Adapter::connect(\$dsn, \$user, \$password); } catch (PDOException \$e) { echo 'Connection failed: ' . \$e->getMessage(); } ?> The next step is opening a new Doctrine_Connection. \$conn = Doctrine_Manager::connection(\$dbh); ?>